KL 1010 then U2 2170 at Schiphol
London Heathrow → Amsterdam → Manchester
Timetable, Amsterdam time
18:40KL 1010 from London Heathrow at the gate
16:20U2 2170 to Manchester leaves the gate
21 h 40 apart on the timetable, overnight
U2 2170 leaves 21 h 40 after KL 1010 arrives on the timetable: more than half a day, so not a connection we count.