U2 2169 then KL 1605 at Schiphol
Manchester → Amsterdam → Rome
Timetable, Amsterdam time
15:40U2 2169 from Manchester at the gate
14:10KL 1605 to Rome leaves the gate
22 h 30 apart on the timetable, overnight
KL 1605 leaves 22 h 30 after U2 2169 arrives on the timetable: more than half a day, so not a connection we count.