U2 2059 then A3 254 at Athens
Manchester → Athens → Mytilene
Timetable, Athens time
19:30U2 2059 from Manchester at the gate
13:55A3 254 to Mytilene leaves the gate
18 h 25 apart on the timetable, overnight
A3 254 leaves 18 h 25 after U2 2059 arrives on the timetable: more than half a day, so not a connection we count.