U2 2059 then A3 256 at Athens
Manchester → Athens → Mytilene
Timetable, Athens time
19:30U2 2059 from Manchester at the gate
17:25A3 256 to Mytilene leaves the gate
21 h 55 apart on the timetable, overnight
A3 256 leaves 21 h 55 after U2 2059 arrives on the timetable: more than half a day, so not a connection we count.