EC 7152 then FR 7543 at Barcelona
Milan → Barcelona → Manchester
Timetable, Barcelona time
14:25EC 7152 from Milan at the gate
11:35FR 7543 to Manchester leaves the gate
21 h 10 apart on the timetable, overnight
FR 7543 leaves 21 h 10 after EC 7152 arrives on the timetable: more than half a day, so not a connection we count.