W4 6021 then FR 7543 at Barcelona
Rome → Barcelona → Manchester
Timetable, Barcelona time
14:30W4 6021 from Rome at the gate
11:35FR 7543 to Manchester leaves the gate
21 h 05 apart on the timetable, overnight
FR 7543 leaves 21 h 05 after W4 6021 arrives on the timetable: more than half a day, so not a connection we count.