AA 380 then AA 5229 at Charlotte
New York LaGuardia → Charlotte → Roanoke
Timetable, Charlotte time
14:19AA 380 from New York LaGuardia at the gate
12:40AA 5229 to Roanoke leaves the gate
22 h 21 apart on the timetable, overnight
AA 5229 leaves 22 h 21 after AA 380 arrives on the timetable: more than half a day, so not a connection we count.