AA 5373 then AA 5585 at Charlotte
Myrtle Beach → Charlotte → Roanoke
Timetable, Charlotte time
15:05AA 5373 from Myrtle Beach at the gate
11:30AA 5585 to Roanoke leaves the gate
20 h 25 apart on the timetable, overnight
AA 5585 leaves 20 h 25 after AA 5373 arrives on the timetable: more than half a day, so not a connection we count.