AA 5389 then AA 5229 at Charlotte
South Bend → Charlotte → Roanoke
Timetable, Charlotte time
13:10AA 5389 from South Bend at the gate
12:40AA 5229 to Roanoke leaves the gate
23 h 30 apart on the timetable, overnight
AA 5229 leaves 23 h 30 after AA 5389 arrives on the timetable: more than half a day, so not a connection we count.