U2 2123 then IB 650 at Fiumicino
Manchester → Rome → Madrid
Timetable, Rome time
16:00U2 2123 from Manchester at the gate
14:45IB 650 to Madrid leaves the gate
22 h 45 apart on the timetable, overnight
IB 650 leaves 22 h 45 after U2 2123 arrives on the timetable: more than half a day, so not a connection we count.