U2 2123 then U2 6111 at Fiumicino
Manchester → Rome → Strasbourg
Timetable, Rome time
16:00U2 2123 from Manchester at the gate
12:35U2 6111 to Strasbourg leaves the gate
20 h 35 apart on the timetable, overnight
U2 6111 leaves 20 h 35 after U2 2123 arrives on the timetable: more than half a day, so not a connection we count.