U2 2994 then FR 5316 at Fiumicino
Frankfurt am Main → Rome → Madrid
Timetable, Rome time
11:10U2 2994 from Frankfurt am Main at the gate
05:45FR 5316 to Madrid leaves the gate
18 h 35 apart on the timetable, overnight
FR 5316 leaves 18 h 35 after U2 2994 arrives on the timetable: more than half a day, so not a connection we count.