U2 5081 then U2 4414 at Fiumicino
Berlin → Rome → Lyon
Timetable, Rome time
09:15U2 5081 from Berlin at the gate
21:35U2 4414 to Lyon leaves the gate
12 h 20 apart on the timetable
U2 4414 leaves 12 h 20 after U2 5081 arrives on the timetable: more than half a day, so not a connection we count.