DE 1591 then DE 1668 at Frankfurt
Kos → Frankfurt am Main → Heraklion
Timetable, Frankfurt am Main time
13:40DE 1591 from Kos at the gate
09:40DE 1668 to Heraklion leaves the gate
20 h apart on the timetable, overnight
DE 1668 leaves 20 h after DE 1591 arrives on the timetable: more than half a day, so not a connection we count.