EC 8306 then U2 8781 at Gatwick
Milan → London → Prague
Timetable, London time
14:10EC 8306 from Milan at the gate
07:10U2 8781 to Prague leaves the gate
17 h apart on the timetable, overnight
U2 8781 leaves 17 h after EC 8306 arrives on the timetable: more than half a day, so not a connection we count.