U2 8306 then U2 841 at Gatwick
Milan → London → Castletown
Timetable, London time
20:55U2 8306 from Milan at the gate
18:20U2 841 to Castletown leaves the gate
21 h 25 apart on the timetable, overnight
U2 841 leaves 21 h 25 after U2 8306 arrives on the timetable: more than half a day, so not a connection we count.