EC 4427 then U2 2460 at Lisbon
Lyon → Lisbon → London Luton
Timetable, Lisbon time
17:10EC 4427 from Lyon at the gate
10:55U2 2460 to London Luton leaves the gate
17 h 45 apart on the timetable, overnight
U2 2460 leaves 17 h 45 after EC 4427 arrives on the timetable: more than half a day, so not a connection we count.