EC 7646 then EC 4428 at Lisbon
Madrid → Lisbon → Lyon
Timetable, Lisbon time
18:25EC 7646 from Madrid at the gate
09:20EC 4428 to Lyon leaves the gate
14 h 55 apart on the timetable, overnight
EC 4428 leaves 14 h 55 after EC 7646 arrives on the timetable: more than half a day, so not a connection we count.