EC 7646 then U2 4428 at Lisbon
Madrid → Lisbon → Lyon
Timetable, Lisbon time
18:25EC 7646 from Madrid at the gate
17:55U2 4428 to Lyon leaves the gate
23 h 30 apart on the timetable, overnight
U2 4428 leaves 23 h 30 after EC 7646 arrives on the timetable: more than half a day, so not a connection we count.