EC 4389 then BA 461 at Madrid
Lyon → Madrid → London Heathrow
Timetable, Madrid time
17:00EC 4389 from Lyon at the gate
13:55BA 461 to London Heathrow leaves the gate
20 h 55 apart on the timetable, overnight
BA 461 leaves 20 h 55 after EC 4389 arrives on the timetable: more than half a day, so not a connection we count.