FR 1330 then FR 5301 at Madrid
Napoli → Madrid → Luxembourg
Timetable, Madrid time
11:50FR 1330 from Napoli at the gate
07:15FR 5301 to Luxembourg leaves the gate
19 h 25 apart on the timetable, overnight
FR 5301 leaves 19 h 25 after FR 1330 arrives on the timetable: more than half a day, so not a connection we count.