FR 3187 then IB 721 at Madrid
Manchester → Madrid → London Heathrow
Timetable, Madrid time
20:25FR 3187 from Manchester at the gate
15:50IB 721 to London Heathrow leaves the gate
19 h 25 apart on the timetable, overnight
IB 721 leaves 19 h 25 after FR 3187 arrives on the timetable: more than half a day, so not a connection we count.