FR 8249 then FR 4066 at Madrid
Milan → Madrid → Catania
Timetable, Madrid time
10:50FR 8249 from Milan at the gate
09:00FR 4066 to Catania leaves the gate
22 h 10 apart on the timetable, overnight
FR 4066 leaves 22 h 10 after FR 8249 arrives on the timetable: more than half a day, so not a connection we count.