FR 9601 then FR 6815 at Madrid
Rome → Madrid → Manchester
Timetable, Madrid time
21:20FR 9601 from Rome at the gate
18:20FR 6815 to Manchester leaves the gate
21 h apart on the timetable, overnight
FR 6815 leaves 21 h after FR 9601 arrives on the timetable: more than half a day, so not a connection we count.