FR 9601 then W4 5374 at Madrid
Rome → Madrid → London Luton
Timetable, Madrid time
21:20FR 9601 from Rome at the gate
19:15W4 5374 to London Luton leaves the gate
21 h 55 apart on the timetable, overnight
W4 5374 leaves 21 h 55 after FR 9601 arrives on the timetable: more than half a day, so not a connection we count.