IB 2241 then U2 7646 at Madrid
Strasbourg → Madrid → Lisbon
Timetable, Madrid time
20:25IB 2241 from Strasbourg at the gatealso VY 5641, QR 6525
18:00U2 7646 to Lisbon leaves the gate
21 h 35 apart on the timetable, overnight
U2 7646 leaves 21 h 35 after IB 2241 arrives on the timetable: more than half a day, so not a connection we count.