U2 2047 then AV 6508 at Madrid
Manchester → Madrid → Frankfurt am Main
Timetable, Madrid time
20:35U2 2047 from Manchester at the gate
17:15AV 6508 to Frankfurt am Main leaves the gate
20 h 40 apart on the timetable, overnight
AV 6508 leaves 20 h 40 after U2 2047 arrives on the timetable: more than half a day, so not a connection we count.