U2 2305 then AV 6208 at Madrid
London Luton → Madrid → Rome
Timetable, Madrid time
19:50U2 2305 from London Luton at the gate
11:40AV 6208 to Rome leaves the gate
15 h 50 apart on the timetable, overnight
AV 6208 leaves 15 h 50 after U2 2305 arrives on the timetable: more than half a day, so not a connection we count.