U2 2305 then UX 1041 at Madrid
London Luton → Madrid → Rome
Timetable, Madrid time
19:55U2 2305 from London Luton at the gate
12:40UX 1041 to Rome leaves the gatealso EY 4330
16 h 45 apart on the timetable, overnight
UX 1041 leaves 16 h 45 after U2 2305 arrives on the timetable: more than half a day, so not a connection we count.