U2 3209 then AV 6204 at Madrid
Edinburgh → Madrid → Rome
Timetable, Madrid time
20:05U2 3209 from Edinburgh at the gate
18:00AV 6204 to Rome leaves the gate
21 h 55 apart on the timetable, overnight
AV 6204 leaves 21 h 55 after U2 3209 arrives on the timetable: more than half a day, so not a connection we count.