U2 3209 then LA 1546 at Madrid
Edinburgh → Madrid → Rome
Timetable, Madrid time
19:10U2 3209 from Edinburgh at the gate
17:05LA 1546 to Rome leaves the gatealso VY 5236, QR 8010, AA 8637
21 h 55 apart on the timetable, overnight
LA 1546 leaves 21 h 55 after U2 3209 arrives on the timetable: more than half a day, so not a connection we count.