VY 5340 then FR 3186 at Madrid
Napoli → Madrid → Manchester
Timetable, Madrid time
08:45VY 5340 from Napoli at the gatealso AA 8561
06:30FR 3186 to Manchester leaves the gate
21 h 45 apart on the timetable, overnight
FR 3186 leaves 21 h 45 after VY 5340 arrives on the timetable: more than half a day, so not a connection we count.