W6 2391 then U2 2048 at Madrid
Budapest → Madrid → Manchester
Timetable, Madrid time
08:45W6 2391 from Budapest at the gate
21:30U2 2048 to Manchester leaves the gate
12 h 45 apart on the timetable
U2 2048 leaves 12 h 45 after W6 2391 arrives on the timetable: more than half a day, so not a connection we count.