W9 5371 then FR 5315 at Madrid
London Luton → Madrid → Rome
Timetable, Madrid time
11:25W9 5371 from London Luton at the gate
08:55FR 5315 to Rome leaves the gate
21 h 30 apart on the timetable, overnight
FR 5315 leaves 21 h 30 after W9 5371 arrives on the timetable: more than half a day, so not a connection we count.