BY 2457 then U2 2201 at Manchester
Heraklion → Manchester → Berlin
Timetable, Manchester time
02:20BY 2457 from Heraklion at the gate
18:45U2 2201 to Berlin leaves the gate
16 h 25 apart on the timetable
U2 2201 leaves 16 h 25 after BY 2457 arrives on the timetable: more than half a day, so not a connection we count.