BY 2681 then U2 2273 at Manchester
Kos → Manchester → Valletta
Timetable, Manchester time
01:45BY 2681 from Kos at the gate
13:50U2 2273 to Valletta leaves the gate
12 h 05 apart on the timetable
U2 2273 leaves 12 h 05 after BY 2681 arrives on the timetable: more than half a day, so not a connection we count.