EC 7501 then U2 2273 at Manchester
Faro → Manchester → Valletta
Timetable, Manchester time
09:15EC 7501 from Faro at the gate
06:15U2 2273 to Valletta leaves the gate
21 h apart on the timetable, overnight
U2 2273 leaves 21 h after EC 7501 arrives on the timetable: more than half a day, so not a connection we count.