FR 1592 then FR 6816 at Manchester
Cologne → Manchester → Milan
Timetable, Manchester time
14:45FR 1592 from Cologne at the gate
06:40FR 6816 to Milan leaves the gate
15 h 55 apart on the timetable, overnight
FR 6816 leaves 15 h 55 after FR 1592 arrives on the timetable: more than half a day, so not a connection we count.