FR 2253 then FR 5624 at Manchester
Lisbon → Manchester → Pisa
Timetable, Manchester time
23:05FR 2253 from Lisbon at the gate
20:25FR 5624 to Pisa leaves the gate
21 h 20 apart on the timetable, overnight
FR 5624 leaves 21 h 20 after FR 2253 arrives on the timetable: more than half a day, so not a connection we count.