FR 2253 then TK 1916 at Manchester
Lisbon → Manchester → Istanbul
Timetable, Manchester time
00:40FR 2253 from Lisbon at the gate
22:30TK 1916 to Istanbul leaves the gate
21 h 50 apart on the timetable
TK 1916 leaves 21 h 50 after FR 2253 arrives on the timetable: more than half a day, so not a connection we count.