FR 7543 then U2 2123 at Manchester
Barcelona → Manchester → Rome
Timetable, Manchester time
13:10FR 7543 from Barcelona at the gate
12:15U2 2123 to Rome leaves the gate
23 h 05 apart on the timetable, overnight
U2 2123 leaves 23 h 05 after FR 7543 arrives on the timetable: more than half a day, so not a connection we count.