U2 2048 then BQ 2322 at Manchester
Madrid → Manchester → Rome
Timetable, Manchester time
22:45U2 2048 from Madrid at the gate
16:00BQ 2322 to Rome leaves the gate
17 h 15 apart on the timetable, overnight
BQ 2322 leaves 17 h 15 after U2 2048 arrives on the timetable: more than half a day, so not a connection we count.