U2 2048 then FR 6816 at Manchester
Madrid → Manchester → Milan
Timetable, Manchester time
13:40U2 2048 from Madrid at the gate
06:40FR 6816 to Milan leaves the gate
17 h apart on the timetable, overnight
FR 6816 leaves 17 h after U2 2048 arrives on the timetable: more than half a day, so not a connection we count.