U2 2122 then FR 1593 at Manchester
Venezia → Manchester → Cologne
Timetable, Manchester time
13:35U2 2122 from Venezia at the gate
11:20FR 1593 to Cologne leaves the gate
21 h 45 apart on the timetable, overnight
FR 1593 leaves 21 h 45 after U2 2122 arrives on the timetable: more than half a day, so not a connection we count.