U2 2124 then BY 2588 at Manchester
Rome → Manchester → Tenerife South
Timetable, Manchester time
18:30U2 2124 from Rome at the gate
10:45BY 2588 to Tenerife South leaves the gate
16 h 15 apart on the timetable, overnight
BY 2588 leaves 16 h 15 after U2 2124 arrives on the timetable: more than half a day, so not a connection we count.