U2 2124 then FR 1227 at Manchester
Rome → Manchester → Reus
Timetable, Manchester time
18:30U2 2124 from Rome at the gate
15:15FR 1227 to Reus leaves the gate
20 h 45 apart on the timetable, overnight
FR 1227 leaves 20 h 45 after U2 2124 arrives on the timetable: more than half a day, so not a connection we count.