U2 2124 then FR 6816 at Manchester
Rome → Manchester → Milan
Timetable, Manchester time
18:30U2 2124 from Rome at the gate
16:35FR 6816 to Milan leaves the gate
22 h 05 apart on the timetable, overnight
FR 6816 leaves 22 h 05 after U2 2124 arrives on the timetable: more than half a day, so not a connection we count.