U2 2124 then LS 881 at Manchester
Rome → Manchester → Alicante
Timetable, Manchester time
18:30U2 2124 from Rome at the gate
16:35LS 881 to Alicante leaves the gate
22 h 05 apart on the timetable, overnight
LS 881 leaves 22 h 05 after U2 2124 arrives on the timetable: more than half a day, so not a connection we count.