U2 2124 then U2 2041 at Manchester
Rome → Manchester → Tenerife South
Timetable, Manchester time
22:50U2 2124 from Rome at the gate
14:50U2 2041 to Tenerife South leaves the gate
16 h apart on the timetable, overnight
U2 2041 leaves 16 h after U2 2124 arrives on the timetable: more than half a day, so not a connection we count.