U2 2124 then U2 3838 at Manchester
Rome → Manchester → Milan
Timetable, Manchester time
22:50U2 2124 from Rome at the gate
15:40U2 3838 to Milan leaves the gate
16 h 50 apart on the timetable, overnight
U2 3838 leaves 16 h 50 after U2 2124 arrives on the timetable: more than half a day, so not a connection we count.